Primary systemic sclerosis heart involvement: A systematic literature review and preliminary data-driven, consensus-based WSF/HFA definition

被引：34

作者：

Bruni, Cosimo ^{[1
]}

Buch, Maya H. ^{[2
,3
]}

Furst, Daniel E. ^{[1
,4
]}

De Luca, Giacomo ^{[5
]}

Djokovic, Aleksandra ^{[6
,7
]}

Dumitru, Raluca B. ^{[8
]}

Giollo, Alessandro ^{[9
]}

Polovina, Marija ^{[6
]}

Steelandt, Alexia ^{[10
]}

Bratis, Kostantinos ^{[11
]}

Suliman, Yossra Atef ^{[12
]}

Milinkovic, Ivan ^{[6
]}

Baritussio, Anna ^{[13
]}

Hasan, Ghadeer ^{[14
]}

Xintarakou, Anastasia ^{[15
]}

Isomura, Yohei ^{[16
]}

Markousis-Mavrogenis, George ^{[17
,18
]}

Tofani, Lorenzo ^{[1
]}

Mavrogeni, Sophie ^{[17
,18
]}

Gargani, Luna ^{[19
]}

Caforio, Alida L. P. ^{[13
,20
]}

Tschoepe, Carsten ^{[21
]}

Ristic, Arsen ^{[6
]}

Klingel, Karin ^{[22
]}

Plein, Sven ^{[23
]}

Behr, Elijah R. ^{[24
,25
]}

Allanore, Yannick ^{[9
]}

Kuwana, Masataka ^{[16
]}

Denton, Christopher P. ^{[26
]}

Khanna, Dinesh ^{[27
]}

Krieg, Thomas ^{[28
]}

Marcolongo, Renzo ^{[13
,29
]}

Galetti, Ilaria ^{[30
]}

Zanatta, Elisabetta ^{[31
]}

Tona, Francesco ^{[32
]}

Seferovic, Petar ^{[6
,7
,33
]}

Matucci-Cerinic, Marco ^{[1
,5
,34
]}

机构：

[1] Univ Florence, Dept Expt & Clin Med, Div Rheumatol, Via Oblate 4, I-50141 Florence, Italy

[2] Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Ctr Musculoskeletal Res, AV Hill Bldg, Manchester M13 9LJ, Lancs, England

[3] Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Biomed Res Ctr, Manchester, Lancs, England

[4] Univ Calif Los Angeles, Dept Rheumatol, Los Angeles, CA USA

[5] Univ Vita Salute San Raffaele, IRCSS San Raffaele Hosp, Unit Immunol Rheumatol Allergy & Rare Dis, Milan, Italy

[6] Univ Hosp Ctr Bezanijska Kosa, Dept Cardiol, Belgrade, Serbia

[7] Univ Belgrade, Sch Med, Belgrade, Serbia

[8] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England

[9] Univ Verona, Rheumatol Sect, Dept Med, Verona, Italy

[10] Univ Paris, Cochin Hosp, Dept Rheumatol, Paris, France

[11] Univ Manchester, Div Cardiovasc Sci, Manchester, Lancs, England

[12] Assuit Univ Hosp, Dept Rheumatol & Rehabil, Fac Med, Assiut, Egypt

[13] Univ Padua, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Cardiol & Cardioimmunol Outpatient Clin, Padua, Italy

[14] Rutgers Robert Wood Johnson Med Sch, Dept Med, New Brunswick, NJ USA

[15] Mitera Gen Hosp, Dept Cardiol, Hygeia Grp, Athens, Greece

[16] Grad Sch Med, Nippon Med Sch, Dept Allergy & Rheumatol, Tokyo, Japan

[17] Onassis Cardiac Surg Ctr, Athens, Attica, Greece

[18] Kapodistrian Univ Athens, Athens, Attica, Greece

[19] CNR, Inst Clin Physiol, Pisa, Italy

[20] European Reference Network Rare Low Prevalence &, Brussels, Belgium

[21] Charite Univ Med Berlin, Charite Campus Virchow Klinikum, Dept Internal Med & Cardiol, Berlin, Germany

[22] Univ Tubingen, Inst Pathol & Neuropathol, Cardiopathol, Tubingen, Germany

[23] Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England

[24] St Georges Univ London, Inst Mol & Clin Sci, Cardiol Clin Acad Grp, London, England

[25] St Georges Univ Hosp NHS Fdn Trust, London, England

[26] Royal Free Hosp, Dept Rheumatol, London, England

[27] Univ Michigan, Dept Internal Med, Div Rheumatol, Scleroderma Program, Ann Arbor, MI 48109 USA

[28] Univ Cologne, Fac Med, Translat Matrix Biol, Cologne, Germany

[29] Univ Hosp Padua, Haematol & Clin Immunol Unit, Padua, Italy

[30] Federat European Scleroderma Assoc FESCA, Brussels, Belgium

[31] Univ Padua, Div Rheumatol, Dept Med, Padua, Italy

[32] Univ Padua, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Padua, Italy

[33] Serbian Acad Arts & Sci, Belgrade, Serbia

[34] Careggi Univ Hosp, Div Rheumatol, Dept Geriatr Med, Florence, Italy

来源：

JOURNAL OF SCLERODERMA AND RELATED DISORDERS | 2022年 / 7卷 / 01期

关键词：

Systemic sclerosis; heart; cardiac involvement; definition; PULMONARY ARTERIAL-HYPERTENSION; DISEASE; PATHOGENESIS; MANAGEMENT; MORTALITY;

D O I：

10.1177/23971983211053246

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Primary heart involvement in systemic sclerosis may cause morpho-functional and electrical cardiac abnormalities and is a common cause of death. The absence of a clear definition of primary heart involvement in systemic sclerosis limits our understanding and ability to focus on clinical research. We aimed to create an expert consensus definition for primary heart involvement in systemic sclerosis. Methods: A systematic literature review of cardiac involvement and manifestations in systemic sclerosis was conducted to inform an international and multi-disciplinary task force. In addition, the nominal group technique was used to derive a definition that was then subject to voting. A total of 16 clinical cases were evaluated to test face validity, feasibility, reliability and criterion validity of the newly created definition. Results: In total, 171 publications met eligibility criteria. Using the nominal group technique, experts added their opinion, provided statements to consider and ranked them to create the consensus definition, which received 100% agreement on face validity. A median 60(5-300) seconds was taken for the feasibility on a single case. Inter-rater agreement was moderate (mKappa (95% CI) = 0.56 (0.46-1.00) for the first round and 0.55 (0.44-1.00) for the second round) and intra-rater agreement was good (mKappa (95% CI) = 0.77 (0.47-1.00)). Criterion validity showed a 78 (73-84)% correctness versus gold standard. Conclusion: A preliminary primary heart involvement in systemic sclerosis consensus-based definition was created and partially validated, for use in future clinical research.

引用

页码：24 / 32

页数：9

共 6 条

[1] PRIMARY SYSTEMIC SCLEROSIS HEART INVOLVEMENT (PSSCHI): A SYSTEMATIC LITERATURE REVIEW (SLR), CONSENSUS-BASED DEFINITION AND PRELIMINARY VALIDATION.
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