Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia

被引：19

作者：

Lapierre, Marion ^{[1
,2
,3
,4
]}

Castet-Nicolas, Audrey ^{[1
,2
,3
,4
,5
]}

Gitenay, Delphine ^{[1
,2
,3
,4
]}

Jalaguier, Stephan ^{[1
,2
,3
,4
]}

Teyssier, Catherine ^{[1
,2
,3
,4
]}

Bret, Caroline ^{[3
,6
,7
]}

Cartron, Guillaume ^{[3
,8
,9
]}

Moreaux, Jerome ^{[3
,6
,7
]}

Cavailles, Vincent ^{[1
,2
,3
,4
]}

机构：

[1] IRCM, F-34298 Montpellier, France

[2] INSERM, U1194, F-34298 Montpellier, France

[3] Univ Montpellier, F-34298 Montpellier, France

[4] Inst Reg Canc Montpellier, F-34298 Montpellier, France

[5] CHU Montpellier, Pharm, F-34298 Montpellier, France

[6] CHU Montpellier, Dept Hematol Biol, F-34298 Montpellier, France

[7] Inst Genet Humaine, CNRS UPR 1142, F-34298 Montpellier, France

[8] CHU Montpellier, Dept Clin Hematol, F-34298 Montpellier, France

[9] UMR CNRS 5235, F-34298 Montpellier, France

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2015年 / 8卷

关键词：

Chronic lymphocytic leukemia; Cell signaling; RIP140/NRIP1; Prognosis marker; ACUTE MYELOID-LEUKEMIA; HEMATOPOIETIC STEM; GENE-EXPRESSION; TRANSCRIPTIONAL REGULATION; GENOMIC ABERRATIONS; SURVIVAL; PROGNOSIS; ESTROGEN; ACTIVATION; DIAGNOSIS;

D O I：

10.1186/s13045-015-0116-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RIP140 is a transcriptional coregulator, (also known as NRIP1), which finely tunes the activity of various transcription factors and plays very important physiological roles. Noticeably, the RIP140 gene has been implicated in the control of energy expenditure, behavior, cognition, mammary gland development and intestinal homeostasis. RIP140 is also involved in the regulation of various oncogenic signaling pathways and participates in the development and progression of solid tumors. During the past years, several papers have reported evidences linking RIP140 to hematologic malignancies. Among them, two recent studies with correlative data suggested that gene expression signatures including RIP140 can predict survival in chronic lymphocytic leukemia (CLL). This review aims to summarize the literature dealing with the expression of RIP140 in CLL and to explore the potential impact of this factor on transcription pathways which play key roles in this pathology.

引用

页数：6

共 50 条

[1] Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia
Marion Lapierre
Audrey Castet-Nicolas
Delphine Gitenay
Stéphan Jalaguier
Catherine Teyssier
Caroline Bret
Guillaume Cartron
Jérôme Moreaux
Vincent Cavaillès
[J]. Journal of Hematology & Oncology, 8
[2] The nuclear receptor co-repressor Nrip1 (RIP140) is essential for female fertility
Roger White
Göran Leonardsson
Ian Rosewell
Mary Ann Jacobs
Stuart Milligan
Malcolm Parker
[J]. Nature Medicine, 2000, 6 : 1368 - 1374
[3] The nuclear receptor co-repressor Nrip1 (RIP140) is essential for female fertility
White, R
Leonardsson, G
Rosewell, I
Jacobs, MA
Milligan, S
Parker, M
[J]. NATURE MEDICINE, 2000, 6 (12) : 1368 - 1374
[4] Transcriptional regulation of the human NRIP1/RIP140 gene by estrogen is modulated by dioxin signalling
Augereau, P
Badia, E
Fuentes, M
Rabenoelina, F
Corniou, M
Derocq, D
Balaguer, P
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[J]. MOLECULAR PHARMACOLOGY, 2006, 69 (04) : 1338 - 1346
[5] A Role for Striated Muscle Nuclear Receptor Co-Regulator RIP140 ( Nrip1) in the Control of Endurance Fitness
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[J]. CIRCULATION, 2023, 148
[6] NRIP1/RIP140 siRNA-mediated Attenuation Counteracts Mitochondrial Dysfunction In Down Syndrome
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[J]. HUMAN MOLECULAR GENETICS, 2014, 23 (16) : 4406 - 4419
[7] Regulation of RIP140 expression by microRNA
Lin, Ya-Lun
Tsai, Nien-Pei
Wei, Li-Na
[J]. FASEB JOURNAL, 2009, 23
[8] RIP140 and LCoR expression in gastrointestinal cancers
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[J]. ONCOTARGET, 2017, 8 (67) : 111161 - 111175
[9] Role of RIP140 in metabolic tissues: Connections to disease
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[J]. FEBS LETTERS, 2008, 582 (01) : 39 - 45
[10] Role of the RIP140 corepressor in ovulation and adipose biology
Steel, JH
White, R
Parker, MG
[J]. JOURNAL OF ENDOCRINOLOGY, 2005, 185 (01) : 1 - 9

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