Retention behavior of amiodarone and some related compounds in reversed-phase liquid chromatography

被引：0
|
作者：
Medvedovici, A
David, V
Albu, F
Farca, A
机构：
[1] Univ Bucharest, Fac Chem, Dept Analyt Chem, Bucharest, Romania
[2] LaborMed Pharma SA, Bucharest, Romania
来源：
REVUE ROUMAINE DE CHIMIE | 2004年 / 49卷 / 09期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Both reversed-phase and ion-pair retention mechanisms of amiodarone, desethylamiodarone and two other related compounds were studied by liquid chromatography. The presence of two iodine atoms in the molecules of these four substances results in a different retention behavior in comparison with many other organic compounds without iodine atoms in their structure. Different mobile phase compositions were studied, and the retention dependence on temperature was used to estimate the main thermodynamic parameters: the enthalpy and entropy of the partition process of analytes between mobile and stationary phases.
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页码：783 / 789
页数：7
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