Antimitogenic effect of Larrea divaricata Cav.: participation in arachidonate metabolism

被引：17
|
作者：
Anesini, C
Genaro, A
Cremaschi, G
Borda, LS
Borda, E
机构：
[1] Univ Buenos Aires, Fac Odontol, Catedra Farmacol, RA-1414 Buenos Aires, DF, Argentina
[2] CEFYBO, CONICET, RA-1414 Buenos Aires, DF, Argentina
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1999年 / 122卷 / 02期
关键词：
Larrea divaricata Cav; zygophyllaceae; antitumoral activity; BW; 5147; cells; lymphoma; leukotrienes; Con A; NDGA; cell viability;
D O I：
10.1016/S0742-8413(98)10114-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aqueous extracts of the leaves of Larrea divaricata Cav. exert antimitogenic effects on tumor cells (BW 5147 murine immature T-lymphoma) and normal, stimulated lymphocytes. The effective concentration was four times smaller in the case of tumor cells than in the case of normal, stimulated lymphocytes. Inhibitor studies of arachidonate pathway suggest that the proliferative effect of the extract is due to the activation of lipoxygenase metabolism, while the inhibitory action could be a direct effect. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：245 / 252
页数：8
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