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Kyoto Prefectural Univ Med, Kamigyo ward, Grad Sch Med Sci, Dept Cardiovasc Med, 465 Kajii-cho Kawaramachi-Hirokoji, Kyoto 6028566, Japan Kyoto Prefectural Univ Med, Kamigyo ward, Grad Sch Med Sci, Dept Cardiovasc Med, 465 Kajii-cho Kawaramachi-Hirokoji, Kyoto 6028566, Japan