Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor subunit composition

被引：21
|
作者：
Bengzon, J [1 ]
Okabe, S
Lindvall, O
McKay, RDG
机构：
[1] Univ Lund Hosp, Wallenberg Neurosci Ctr, Sect Restorat Neurol, S-22185 Lund, Sweden
[2] Natl Inst Biosci & Human Technol, Tsukuba, Ibaraki 305, Japan
[3] NINDS, Mol Biol Lab, Bethesda, MD 20892 USA
来源：
EUROPEAN JOURNAL OF NEUROSCIENCE | 1999年 / 11卷 / 03期
关键词：
D O I：
10.1046/j.1460-9568.1999.00500.x
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of NR2D under control of the calcium/calmodulin kinase II alpha subunit (alpha CaMKII) promoter. The NR2D subunit is normally present at very low levels in the mature forebrain. Transgenic mice showed a marked reduction of amygdala kindling development. Spread of epileptic activity was retarded and generalized seizures appeared later in animals overexpressing NR2D compared with wild-type mice. The progressive lengthening of epileptiform activity, which normally occurs in kindling, was also dampened in transgenic animals. We conclude that NMDA receptor subunit composition determines the progression of experimental epilepsy.
引用
收藏
页码：916 / 922
页数：7
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