Multistability and robustness of the MAPK pathway

被引：0
|
作者：
Blanchini, Franco [1 ]
Franco, Elisa [2 ]
机构：
[1] Univ Udine, Dipartimento Math & Informat, I-33100 Udine, Italy
[2] CALTECH, Div Engn & Appl Sci, Pasadena, CA 91125 USA
来源：
2011 50TH IEEE CONFERENCE ON DECISION AND CONTROL AND EUROPEAN CONTROL CONFERENCE (CDC-ECC) | 2011年
关键词：
CELL FATE; SYSTEMS; NETWORKS;
D O I：
暂无
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
In this paper, we propose a qualitative model of the MAPK signaling cascade and analyze its multi-stability properties. Building on our previous work, we employ Lyapunov and invariant sets theory to analyze the system. In particular we focus on the first stage of a class of MAPK cascades, known as the Mos subsystem, which is the target of a positive feedback loop. Under general assumptions, we show that the system is bistable when three equilibria are present, regardless of the specific feedback dynamics.
引用
收藏
页码：2214 / 2219
页数：6
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