Life cycle concept was applied to analyse and assess some municipal solid waste (MSW) management scenarios in terms of environmental impacts, particularised for Iasi city, Romania, where approximately 380 kg/cap/yr of waste are generated. Currently, the management processes include temporary storage, collection, transport and landfilling, but separate collection, sorting, recycling and composting of solid waste, which should be addressed according to the National Strategy and European policy for waste. Four different scenarios were elaborated as alternatives to the existing waste management system in Iasi, which include both previously applied and current waste management alternatives, as well as some advanced practices. The effectiveness of the scenarios was evaluated in terms of environmental impacts based on Life Cycle Analysis, supported by GaBi software. Some environmental impact categories (acidification, eutrophication, global warming, human toxicity, and photochemical ozone generation potentials, carcinogenic substances, heavy metals, winter smog, photochemical ozone formation) were estimated based on several impact assessment methods associated to GaBi software (CML 2001, CML 96, EDIP 2003, E195). The study emphasises the importance of system boundaries for the life cycle impact assessment process and consequently for the optimal waste management alternative.