Differences in Motor and Cognitive Function in Patients With Parkinson's Disease With and Without Orthostatic Hypotension

被引：38

作者：

Hohler, Anna D. ^{[1
,2
]}

Zuzuarregui, Jose-Rafael P. ^{[1
]}

Katz, Douglas I. ^{[1
,2
]}

DePiero, T. Joy ^{[1
,2
]}

Hehl, Christina L. ^{[2
]}

Leonard, Alissa ^{[2
]}

Allen, Valerie ^{[2
]}

Dentino, Jill ^{[2
]}

Gardner, Maura ^{[2
]}

Phenix, Heidi ^{[2
]}

Saint-Hilaire, Marie ^{[1
]}

Ellis, Terry ^{[2
,3
]}

机构：

[1] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[2] Braintree Rehabil Hosp, Braintree, MA USA

[3] Boston Univ, Sargent Coll, Boston, MA 02118 USA

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2012年 / 122卷 / 05期

关键词：

cognition; inpatient rehabilitation; orthostasis; Parkinson's disease; TEST-RETEST RELIABILITY; BERG BALANCE SCALE; PEOPLE; DYSFUNCTION;

D O I：

10.1080/00207454.2012.642038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Patients with Parkinson's disease (PD) often present with orthostatic hypotension (OH) as a result of the dysautonomia associated with the disease or as a side effect of the dopaminergic medications used to treat the disease. The purpose of this study was to investigate differences in motor and cognitive function in patients with PD with and without OH. Forty-four patients with a diagnosis of PD were evaluated and stratified by the presence of OH based on orthostatic blood pressure recordings. Both groups underwent assessments of motor and cognitive function. OH was present in 17 of 44 patients (39%) with PD. These patients with OH had significantly lower scores in gross motor, balance, and cognitive function (p < .05). No significant difference between groups was found in the finger tapping scores. These results suggest that patients with PD should be routinely screened for OH as it commonly occurs and may negatively impact gross motor, balance, and cognitive function.

引用

页码：233 / 236

页数：4

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