Elevated lipoprotein(a) and lipoprotein-associated phospholipase A2 are associated with unfavorable functional outcomes in patients with ischemic stroke

被引：14
|
作者：
Jiang, Xue [1 ,2 ,3 ]
Xu, Jie [1 ,2 ,3 ]
Hao, Xiwa [1 ,2 ,3 ,6 ]
Xue, Jing [1 ,2 ,3 ]
Li, Ke [1 ,2 ,3 ]
Jin, Aoming [1 ,2 ,3 ]
Lin, Jinxi [1 ,2 ,3 ]
Meng, Xia [1 ,2 ,3 ]
Zheng, Lemin [1 ,2 ,3 ,4 ,5 ]
Wang, Yongjun [1 ,2 ,3 ]
机构：
[1] Capital Med Univ, Beijing Tiantan Hosp, 119 South 4th Ring West Rd, Beijing 100070, Peoples R China
[2] Capital Med Univ, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
[3] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
[4] Peking Univ, Inst Cardiovasc Sci, 38 Xueyuan Rd, Beijing 100871, Peoples R China
[5] Peking Univ, Hlth Sci Ctr,Beijing Key Lab Cardiovasc Receptors, Inst Syst Biomed,NHC Key Lab Cardiovasc Mol Biol, Sch Basic Med Sci,Key Lab Mol Cardiovasc Sci,Mini, 38 Xueyuan Rd, Beijing 100871, Peoples R China
[6] Baotou Ctr Hosp, Dept Neurol, Baotou, Inner Mongolia, Peoples R China
来源：
JOURNAL OF NEUROINFLAMMATION | 2021年 / 18卷 / 01期
基金：
中国国家自然科学基金; 国家重点研发计划; 中国博士后科学基金;
关键词：
Lipoprotein(a); Lipoprotein-associated phospholipase A(2); Inflammation; Functional outcomes; Ischemic stroke; AORTIC-VALVE STENOSIS; LONG-TERM; RISK; DISEASE; MORTALITY; INSIGHTS;
D O I：
10.1186/s12974-021-02359-w
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background The association of lipoprotein(a) [Lp(a)] and stroke functional outcomes was conflicting. The aim of the study was to clarify whether high Lp(a) is associated with unfavorable functional outcomes in patients with ischemic stroke. Methods A total of 9709 individuals from the third China National Stroke Registry cohort were recruited. Plasma level of Lp(a) at admission was measured with enzyme-linked immunosorbent assay. The cut-off was set at the median for Lp(a). Functional outcome was assessed using the modified Rankin scale (mRS) at 3 months and 1 year after ischemic stroke. The association between Lp(a) and functional outcomes was evaluated using a logistic regression model. Results The median age was 63.0 years, and 31.1% participants were women. Patients in higher Lp(a) group had higher incidences of unfavorable functional outcomes at 3 months. In logistic regression model, elevated Lp(a) levels were associated with unfavorable functional outcomes at 3 months (Q4 vs. Q1: odds ratio 1.33, 95% confidence interval 1.11-1.61). Subgroup analysis showed that in the lower Lp-PLA(2) group, Lp(a) level was not associated with functional outcomes, but in the higher Lp-PLA(2) group, Lp(a) level was significantly associated with functional outcomes. After grouped by different levels of Lp(a) and Lp-PLA(2), the Lp(a) high/ Lp-PLA(2) high group showed the highest incidence of unfavorable functional outcomes at 3 months and 1 year. Conclusions Elevated Lp(a) level is associated with unfavorable functional outcomes in patients with ischemic stroke. The increment in both Lp(a) and Lp-PLA(2) are associated with unfavorable functional outcomes at 3 months and 1 year after ischemic stroke.
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页数：8
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