Composition analysis and immuno-modulatory effect of okra (Abelmoschus esculentus L.) extract

被引：33

作者：

Sheu, Shyang-Chwen ^{[1
]}

Lai, Mei-Huei ^{[1
]}

机构：

[1] Natl Pingtung Univ Sci & Technol, Dept Food Sci, Neipu 91201, Pingtung, Taiwan

来源：

FOOD CHEMISTRY | 2012年 / 134卷 / 04期

关键词：

Okra; Abelmoschus esculentus L; Polysaccharide; Dendritic cell; Cytokine; DENDRITIC CELLS; STRUCTURAL-CHARACTERIZATION; FUNCTIONAL MATURATION; GLUCAN; POLYSACCHARIDES; RECEPTOR; BINDING;

D O I：

10.1016/j.foodchem.2012.03.110

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The aim of this study was to analyse the composition of okra (Abelmoschus esculentus L) extract and investigate the effect of A. esculentus L polysaccharides (AE-PS) on the maturation and function of dendritic cells (DCs) derived from rat bone marrow hematopoietic cells (BMHCs) in vitro. BMHC-derived immature DCs (BMHC-imDCs) were extracted from rats and treated with AE-PS. The hydrolysed okra extract contained 0.6% beta-1, 3-D-glucan. AE-PS induced the presence of polymorphic nuclei and elongated protrusion in the BHMC-imDCs, indicating DC activation. Treatment with 100 mu g/mL of AE-PS increased the MHC class II and CD80/86 expression levels by 41% and 42%, respectively. Treated cells had reduced endocytosis activity. The secretion of IL-12 and IFN-gamma increased significantly by 120% and 75%, respectively, when treated with 100 mu g/mL of AE-PS. Moreover, IL-10 production was reduced by 66%. In conclusion, AE-PS exhibits stimulatory effects on rat dendritic cells and promotes the secretion of T(H)1 cytokines. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1906 / 1911

页数：6

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