INCREASED CD47-THROMBOSPONDIN-1 INDUCTION OF SHP-1 PHOSPHATASE CONTRIBUTES TO POST-TRAUMA T CELL HYPORESPONSIVENESS BY DEPHOSPHORYLATING NFKB

被引：0
|
作者：
Bandyopadhyay, G. [1 ]
Kundimi, S. [1 ]
Bankey, P. E. [1 ]
Miller-Graziano, C. L. [1 ]
机构：
[1] Univ Rochester, Med Ctr, Rochester, NY 14642 USA
来源：
SHOCK | 2011年 / 35卷
关键词：
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
引用
收藏
页码：65 / 65
页数：1
相关论文
共 8 条
  • [1] SHP-1 phosphatase activity counteracts increased T cell receptor affinity
    Hebeisen, Michael
    Baitsch, Lukas
    Presotto, Danilo
    Baumgaertner, Petra
    Romero, Pedro
    Michielin, Olivier
    Speiser, Daniel E.
    Rufer, Nathalie
    JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (03): : 1044 - 1056
  • [2] Thrombospondin-1:CD47 signaling contributes to the development of T cell exhaustion in cancer
    Weng, Chien-Huan
    Assouvie, Anais
    Dong, Lauren
    Beltra, Jean-Christophe
    Budhu, Sadna
    Mangarin, Levi
    Marouf, Yacine
    Morgado-Palacin, Lucia
    Liu, Cailian
    Monette, Sebastien
    Khan, Jonathan
    Schulze, Isabell
    Zamarin, Dmitriy
    Hamadene, Linda
    Samaan, Fadi
    Hirschhorn, Daniel
    Pourpe, Stephane
    Schroder, David
    Zappasodi, Roberta
    Holland, Pamela
    Anandasabapathy, Niroshana
    Wherry, John
    Wolchok, Jedd D.
    Merghoub, Taha
    CANCER IMMUNOLOGY RESEARCH, 2025, 13 (02)
  • [3] Using zinc finger nucleases to knockout the protein tyrosine phosphatase, SHP-1, in human CD8+ T cells for increased cancer cell killing
    Wehenkel, Sophie
    Ager, Ann
    Matthews, James
    HUMAN GENE THERAPY, 2013, 24 (05) : A19 - A20
  • [4] Absence of activation of SHP-1 phosphotryosine phosphatase results in increased fyn tyrosine kinase activity in human T cell anergy.
    Boussiotis, VA
    Berezovskaya, A
    Nadler, LM
    BLOOD, 1997, 90 (10) : 78 - 78
  • [5] Posttrauma Increased Thrombospondin-1 Production Contributes to Increased Sensitivity of T Cell to TRAIL-mediated Post-injury Apoptosis
    Bandyopadhyay, Gautam
    Bandyopadhyay, Sanjukta
    Kundimi, Sreenath
    Bankey, Paul
    Miller-Graziano, Carol
    CLINICAL IMMUNOLOGY, 2010, 135 : S72 - S72
  • [6] SRC-HOMOLOGY DOMAIN CONTAINING PHOSPHATASE-1 (SHP-1) INHIBITION BY SODIUM STIBOGLUCONATE (SSG) AUGMENTS T CELL RESPONSE IN IMMUNODEPRESSED HEALTHY GERIATRIC SUBJECTS AND TRAUMA PATIENTS
    Bandyopadhyay, Gautam
    Bankey, Paul
    Miller-Graziano, Carol
    INFLAMMATION RESEARCH, 2012, 61 : S11 - S11
  • [7] Targeting Src homology 2 domain-containing tyrosine phosphatase (SHP-1) into lipid rafts inhibits CD3-induced T cell activation
    Su, MWC
    Yu, CL
    Burakoff, SJ
    Jin, YJ
    JOURNAL OF IMMUNOLOGY, 2001, 166 (06): : 3975 - 3982
  • [8] CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: Involvement of SH2-containing phosphotyrosine phosphatase SHP-1
    Perez-Villar, JJ
    Whitney, GS
    Bowen, MA
    Hewgill, DH
    Aruffo, AA
    Kanner, SB
    MOLECULAR AND CELLULAR BIOLOGY, 1999, 19 (04) : 2903 - 2912
1