Acute Pneumonia Caused by Clinically Isolated Legionella pneumophila Sg 1, ST 62: Host Responses and Pathologies in Mice

被引：1

作者：

Trousil, Jiri ^{[1
]}

Frgelecova, Lucia ^{[2
]}

Kubickova, Pavla ^{[3
]}

Rehakova, Kristina ^{[4
]}

Drasar, Vladimir ^{[5
]}

Matejkova, Jana ^{[6
]}

Stepanek, Petr ^{[1
]}

Pavlis, Oto ^{[3
]}

机构：

[1] Czech Acad Sci, Inst Macromol Chem, Heyrovskeho Nam 2, Prague 16200, Czech Republic

[2] Univ Vet Sci Brno, Fac Vet Med, Dept Pathol Morphol & Parasitol, Palackeho Tr 1946-1, Brno 61242, Czech Republic

[3] Mil Med Agcy, Mil Hlth Inst, Tychonova 1, Prague 16000, Czech Republic

[4] Univ Vet Sci Brno, Fac Vet Med, Small Anim Clin Lab, Palackeho Tr 1946-1, Brno 61242, Czech Republic

[5] Publ Hlth Inst Ostrava, Natl Legionella Reference Lab, Masarykovo Namesti 16, Vyskov 68201, Czech Republic

[6] Charles Univ Prague, Motol Univ Hosp, Fac Med 2, Dept Med Microbiol, V Uvalu 84, Prague 15006, Czech Republic

来源：

MICROORGANISMS | 2022年 / 10卷 / 01期

关键词：

legionellosis; histopathology; A; J mouse; lung infection; mouse model; inflammatory; RESPIRATORY-DISTRESS-SYNDROME; SEQUENCE-BASED TYPES; LEGIONNAIRES-DISEASE; LUNG INFECTION; GUINEA-PIGS; SEROGROUPS; INFLAMMATION; MYOCARDITIS; BIOMARKERS; POSSESSES;

D O I：

10.3390/microorganisms10010179

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Legionnaires' disease is a severe form of lung infection caused by bacteria belonging to the genus Legionella. The disease severity depends on both host immunity and L. pneumophila virulence. The objective of this study was to describe the pathological spectrum of acute pneumonia caused by a virulent clinical isolate of L. pneumophila serogroup 1, sequence type 62. In A/JOlaHsd mice, we compared two infectious doses, namely, 10(4) and 10(6) CFU, and their impact on the mouse status, bacterial clearance, lung pathology, and blood count parameters was studied. Acute pneumonia resembling Legionnaires' disease has been described in detail.

引用

页数：15

共 4 条

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