The Historical Evolution of Ocular Tuberculosis: Past, Present, and Future

被引：1

作者：

Betzler, Bjorn Kaijun ^{[1
,2
]}

Gunasekeran, Dinesh Visva ^{[3
,4
,5
,6
]}

Kempen, John ^{[7
,8
,9
,10
]}

Smith, Justine R. ^{[11
]}

McCluskey, Peter ^{[12
]}

Quan Dong Nguyen ^{[13
]}

Pavesio, Carlos ^{[4
,5
]}

Gupta, Vishali ^{[14
]}

Agrawal, Rupesh ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

[2] Singapore Eye Res Inst, Singapore, Singapore

[3] Tan Tock Seng Hosp, Natl Healthcare Grp Eye Inst, Singapore, Singapore

[4] UCL, Moorfields Eye Hosp, London, England

[5] UCL, Biomed Res Ctr, Inst Ophthalmol, London, England

[6] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore

[7] Massachusetts Eye & Ear Infirm, Dept Ophthalmol, Boston, MA 02114 USA

[8] Harvard Med Sch, Boston, MA 02115 USA

[9] MCM Gen Hosp, MyungSung Christian Med Ctr MCM Eye Unit, Addis Ababa, Ethiopia

[10] MyungSung Med Sch, Addis Ababa, Ethiopia

[11] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, SA, Australia

[12] Sydney Eye Hosp, Save Sight Inst, Sydney, NSW, Australia

[13] Stanford Med Sch, Byers Eye Inst, Stanford, CA USA

[14] Postgrad Inst Med Educ & Res PGIMER, Adv Eye Ctr, Chandigarh, India

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2022年 / 30卷 / 03期

基金：

英国医学研究理事会;

关键词：

History; tuberculosis; ocular tuberculosis; consumption; inflammation; uveitis; artificial intelligence; proteomics; UVEITIS; DIAGNOSIS; ETIOLOGY; PATTERNS; EYE; EXPERIENCE; THERAPY;

D O I：

10.1080/09273948.2021.1992446

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Ocular involvement is a rare manifestation of tuberculosis. Four key issues historically faced by clinicians when diagnosing and treating ocular tuberculosis - diagnostic uncertainty, naturally heterogeneous presentations, limitations of existing laboratory diagnostic tools, and non-uniform treatment guidelines - continue to test today's physicians. Unparalleled scientific and clinical developments over the past century have greatly expanded the knowledge surrounding this challenging ophthalmic condition. Experience with large volumes of cases at tuberculosis-endemic centres has led to recent growth in knowledge and physician experience, perhaps more so in developing countries. Looking forward, the role of diverse new technologies, including artificial intelligence and proteomics, will advance ocular tuberculosis research. Efforts have been made to address the lack of standardized nomenclature, diagnostic uncertainty, and unvalidated, geographically variable treatment guidelines.

引用

页码：593 / 599

页数：7

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