Vaginal microbiome diversity and preterm birth: results of a nested case-control study in Peru

被引:21
|
作者
Blostein, Freida [1 ]
Gelaye, Bizu [2 ]
Sanchez, Sixto E. [3 ]
Williams, Michelle A. [2 ]
Foxman, Betsy [1 ]
机构
[1] Univ Michigan, Thomas Francis Sch Publ Hlth, M5108 SPH 2,1415 Washington Hts, Ann Arbor, MI 48109 USA
[2] Harvard TH Chan Sch Publ Hlth, Boston, MA USA
[3] Univ San Martin Porres, Fac Med, Lima, Peru
关键词
Premature birth; Microbiota; Host-microbial interactions; Molecular epidemiology; EPIDEMIOLOGY; PREGNANCY;
D O I
10.1016/j.annepidem.2019.11.004
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Purpose: Preterm birth (PTB) is a major cause of neonatal mortality. The vaginal microbiome is associated with PTB, but results vary across racial/ethnic populations. Some evidence suggests gestational age affects this association. We investigated these associations in a novel population, conducting a post hoc analysis assessing if associations differed between women swabbed at different gestational ages. Methods: We compared vaginal microbiomes from women with PTB (n = 25) to a random sample of women with term births (n = 100) among participants in the Pregnancy Outcomes, Maternal and Infant Study, conducted in Lima, Peru. Using DADA2, we identified taxa from 16S DNA sequencing and used Dirichlet multinomial mixture models to group into community state types (CSTs). Results: If gestational age at sampling was not considered, no CST (diverse, Lactobacillus-dominated or Lactobacillus iners-dominated), was associated with PTB. Among women sampled before 12 weeks' gestation, women with Lactobacillus-dominated CSTs were less likely to have a PTB than those with a diverse CST. Among those swabbed between 12 and 16 weeks' gestation, the reverse was true. Conclusions: Our study supports previous literature suggesting that what constitutes a healthy vaginal microbiome varies by race/ethnicity. Longitudinal studies are necessary to disentangle effects of vaginal microbiome differences over gestation. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页码:28 / 34
页数:7
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