Olopatadine/mometasone combination nasal spray in allergic rhinitis: a profile of its use

Olopatadine/mometasone furoate combination nasal spray -(Ryaltris (R); referred to hereafter as olopatadine/mometasone), a convenient fixed-dose combination (FDC) of the antihistamine olopatadine and the corticosteroid mometasone furoate, is approved in Australia for the treatment of symptoms associated with allergic rhinitis (AR) and rhinoconjunctivitis in patients 12 years of age and older. Olopatadine/mometasone is an effective treatment for seasonal and perennial AR, providing statistically significant and clinically meaningful relief of nasal symptoms relative to monocomponents and/or placebo in clinical trials. Ocular symptoms of AR were also improved with olopatadine/mometasone. Benefits of olopatadine/mometasone were maintained over 52 weeks of treatment in adults and adolescents with perennial AR. Olopatadine/mometasone is generally well tolerated, with most treatment-emergent adverse events being of mild to moderate severity.