Novel therapeutic strategies for patients with triple-negative breast cancer

被引：21
|
作者：
Zhang, Jun-Fei [1 ]
Liu, Jia [1 ,2 ]
Wang, Yu [1 ,2 ]
Zhang, Bin [1 ,2 ]
机构：
[1] Inner Mongolia Univ Nationalities, Affiliated Hosp, Tongliao, Inner Mongolia, Peoples R China
[2] Inner Mongolia Univ Nationalities, Med Chem & Pharmacol Inst, 1742 Holin He St, Tongliao 028007, Inner Mongolia, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2016年 / 9卷
基金：
中国国家自然科学基金;
关键词：
therapeutic strategies; TNBC; targeted agents; TUMOR-INFILTRATING LYMPHOCYTES; GROWTH-FACTOR RECEPTOR; PATHOLOGICAL COMPLETE RESPONSE; NEOADJUVANT CHEMOTHERAPY; AFRICAN-AMERICAN; PHASE-II; CARBOPLATIN; PACLITAXEL; INIPARIB; SURVIVAL;
D O I：
10.2147/OTT.S105716
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Triple-negative breast cancer (TNBC) represents a very heterogeneous group of breast diseases. Currently, the backbone of therapy for TNBC is mainly chemotherapy as there are no effective specific targeted agents approved to treat TNBC. Despite initial responses to chemotherapy, resistance frequently and rapidly develops and metastatic TNBC has a poor prognosis. Therefore, new targeted strategies are, accordingly, urgently needed. This article discusses the recent developments in targeted agents explored for TNBC, aiming to offer novel therapeutic strategies that can potentially assist in designing personalized therapeutics in the future as well as provide the basis for further research in an attempt to target TNBC.
引用
收藏
页码：6519 / 6528
页数：10
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