Molecular mechanisms for plasmacytoid dendritic cell function and development

被引：7
|
作者：
Kaisho, Tsuneyasu [1 ,2 ,3 ]
机构：
[1] RIKEN, Host Def Lab, Res Ctr Allergy & Immunol, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan
[2] Osaka Univ, Grad Sch Med, Dept Allergy & Immunol, Suita, Osaka 5650871, Japan
[3] Yokohama City Univ, Grad Sch Nanobiosci, Dept Supramol Biol, Tsurumi Ku, Kanagawa 2300045, Japan
来源：
VACCINE | 2010年 / 28卷 / 50期
关键词：
Dendritic cell; Plasmacytoid dendritic cell; Toll-like receptor; I kappa B kinase; Type I interferon; KAPPA-B;
D O I：
10.1016/j.vaccine.2010.09.025
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dendritic cells (DCs) are activated by immune adjuvants in a DC subset-specific manner. Plasmacytoid DC (pDC) is a unique subset that senses nucleic acid immune adjuvants only through two Toll-like receptors (TLRs), TLR7 and TLR9 and produces large amounts of type I interferons. Here 1 review recent trend in pDC function and development. (c) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8046 / 8047
页数：2
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