Synthesis of α-Amino Acid N-Carboxyanhydrides

被引：9

作者：

Laconde, Guillaume ^{[1
]}

Amblard, Muriel ^{[1
]}

Martinez, Jean ^{[1
]}

机构：

[1] Univ Montpellier, Fac Pharm, ENSCM, Inst Biomol Max Mousseron,IBMM UMR 5247 CNRS, F-34093 Montpellier, France

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 16期

关键词：

PHOSGENE-FREE SYNTHESIS; ACTIVATION; ANHYDRIDES; BOND;

D O I：

10.1021/acs.orglett.1c02224

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple phosgene- and halogen-free method for synthesizing a-amino acid N-carboxyanhydrides (NCAs) is described. The reaction between Boc-protected alpha-amino acids and T3P reagent gave the corresponding NCA derivatives in good yield and purity with no detectable epimerization. The process is safe, is easy-to-operate, and does not require any specific installation. It generates nontoxic, easy to remove byproducts. It can apply to the preparation of NCAs for the on-demand on-site production of either little or large quantities.

引用

页码：6412 / 6416

页数：5

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