Recent chemoenzymatic total syntheses of natural and unnatural products: Codeine, balanol, pancratistatin, and oseltamivir

被引：24
|
作者：
Hudlicky, Tomas [1 ,2 ]
机构：
[1] Brock Univ, Dept Chem, St Catharines, ON L2S 3A1, Canada
[2] Brock Univ, Ctr Biotechnol, St Catharines, ON L2S 3A1, Canada
来源：
PURE AND APPLIED CHEMISTRY | 2010年 / 82卷 / 09期
基金：
加拿大自然科学与工程研究理事会; 加拿大创新基金会;
关键词：
balanol; chemoenzymatic synthesis; codeine; oseltamivir; pancratistatin; Tamiflu; toluene-dioxygenase; ENANTIOSELECTIVE TOTAL-SYNTHESIS; RADICAL CYCLIZATION APPROACH; FORMAL TOTAL-SYNTHESIS; ENZYMATIC DIHYDROXYLATION; RING CONSTRUCTION; BURGESS REAGENT; CHIRAL VERSION; MORPHINE; (-)-MORPHINE; (-)-GALANTHAMINE;
D O I：
10.1351/PAC-CON-09-10-07
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Presented here is a short summary of the recent accomplishments in total synthesis in our laboratories. In particular, recent generations of the syntheses of pancratistatin derivatives, codeine, balanol, and oseltamivir (Tamiflu) are described in relation to their common chemoenzymatic origin in toluene-dioxygenase-mediated dioxygenation of aromatic substrates. Perspectives and projections are discussed in the conclusion.
引用
收藏
页码：1785 / 1796
页数：12
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