Cooperative Catalytic Reactions Using Organocatalysts and Transition Metal Catalysts: Enantioselective Propargylic Alkylation of Propargylic Esters with Aldehydes

被引：70

作者：

Yoshida, Akiko ^{[1
]}

Ikeda, Masahiro ^{[1
]}

Hattori, Gaku ^{[1
]}

Miyake, Yoshihiro ^{[1
]}

Nishibayashi, Yoshiaki ^{[1
]}

机构：

[1] Univ Tokyo, Sch Engn, Inst Engn Innovat, Bunkyo Ku, Tokyo 1138656, Japan

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 04期

关键词：

ASYMMETRIC REDUCTIVE AMINATION; BOND-FORMING HYDROGENATION; ACID BINARY-SYSTEM; BRONSTED ACID; SUBSTITUTION-REACTIONS; ALPHA-ALKYLATION; MICHAEL ADDITION; ALLENYLIDENE COMPLEXES; ALLYLIC ALKYLATION; RELAY CATALYSIS;

D O I：

10.1021/ol1027865

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective propargylic alkylation of propargylic esters with aldehydes in the presence of a copper complex and an optically active secondary amine as cocatalysts has been found to give the corresponding propargylic alkylated products in good yields as a mixture of two diastereoisomers with a high enantioselectivity.

引用

页码：592 / 595

页数：4

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