The role of neuronal nitric oxide synthase in cocaine-induced conditioned place preference

被引：66
|
作者：
Itzhak, Y
Martin, JL
Black, MD
Huang, PL
机构：
[1] Univ Miami, Sch Med, Dept Biochem & Mol Biol R629, Miami, FL 33101 USA
[2] Massachusetts Gen Hosp, Dept Med, Cardiovasc Res Ctr, Charlestown, MA 02129 USA
[3] Harvard Univ, Sch Med, Dept Med, Cardiovasc Res Ctr, Charlestown, MA 02129 USA
来源：
NEUROREPORT | 1998年 / 9卷 / 11期
关键词：
cocaine; conditioned place preference; knockout mice; nitric oxide; 7-nitroindazole; reward;
D O I：
10.1097/00001756-199808030-00011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
PREVIOUS studies suggested the involvement of the neuronal nitric oxide synthase (nNOS) in the development of sensitization to psychostimulants. In the present study we investigated the role of nNOS in the rewarding properties of cocaine. Swiss Webster mice treated with cocaine (20 mg/kg) and saline every other day for 8 days (four drug and four saline sessions) developed conditioned place preference (CPP) for the drug-paired compartment of the cage. Pretreatment with the nNOS inhibitor, 7-nitroindazole (7-NI; 25mg/kg), completely blocked cocaine-induced CPP. Mice deficient for the nNOS gene (homozygote nNOS(-/-) mice) were resistant to cocaine-induced CPP, while wild-type nNOS(+/+) mice developed a marked CPP following cocaine administration. Both, the pharmacological and genetic manipulations of nNOS suggest that nitric oxide (NO) is involved in the rewarding properties of cocaine. NeuroReport 9: 2485-2488 (C) 1998 Rapid Science Ltd.
引用
收藏
页码：2485 / 2488
页数：4
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