Glioblastoma, Cancer Stem Cells and Hypoxia

被引：94

作者：

Bar, Eli E. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Pathol, Sch Med, Baltimore, MD 21287 USA

来源：

BRAIN PATHOLOGY | 2011年 / 21卷 / 02期

关键词：

cancer stem cells; CD133; digoxin; HIF; hypoxia; glioma; side population; INDUCIBLE FACTOR 1-ALPHA; ENDOTHELIAL GROWTH-FACTOR; SMALL-MOLECULE INHIBITOR; OXYGEN CONCENTRATION; NEURAL STEM; FACTOR-I; TRANSCRIPTIONAL ACTIVITY; PROTEASOMAL DEGRADATION; HIF-1-ALPHA SYNTHESIS; COLON-CANCER;

D O I：

10.1111/j.1750-3639.2010.00460.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glioblastoma (GBM) prognosis remains dismal, with most patients succumbing to disease within 1 or 2 years of diagnosis. Recent studies have suggested that many solid tumors, including GBM, are maintained by a subset of cells termed cancer stem cells (CSCs). It has been shown that these cells are inherently radio- and chemotherapy resistant, and may be maintained in vivo in a niche characterized by reduced oxygen tension (hypoxia). This review examines the recently described effects of hypoxia on CSC in GBM, and the potential promise in targeting the hypoxic pathway therapeutically.

引用

页码：119 / 129

页数：11

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