Lipid radicals cause light-induced retinal degeneration

被引：14

作者：

Enoki, Masataka ^{[1
]}

Shinto, Saki ^{[1
]}

Matsuoka, Yuta ^{[1
]}

Otsuka, Ayasa ^{[1
]}

Kaidzu, Sachiko ^{[2
]}

Tanito, Masaki ^{[2
]}

Shibata, Takahiro ^{[3
,4
,5
]}

Uchida, Koji ^{[6
]}

Ohira, Akihiro ^{[2
]}

Yamatoa, Mayumi ^{[1
]}

Yamada, Ken-ichi ^{[1
,5
]}

机构：

[1] Kyushu Univ, Fac Pharmaceut Sci, Phys Chem Life Sci Lab, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Japan

[2] Shimane Univ, Sch Med, Dept Ophthalmol, 89-1 Enya Cho, Izumo, Shimane, Japan

[3] Nagoya Univ, Grad Sch Bioagr Sci, Lab Food & Biodynam, Chikusa Ku, Furo Cho, Nagoya, Aichi, Japan

[4] Nagoya Univ, Sch Agr Sci, Chikusa Ku, Furo Cho, Nagoya, Aichi, Japan

[5] Japan Sci & Technol Agcy, PRESTO, 4-1-8 Hon Cho, Kawaguchi, Saitama, Japan

[6] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Lab Food Chem,Bunkyo ku, 1-1-1 Yayoi, Tokyo, Japan

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 79期

关键词：

MACULAR DEGENERATION; OXIDATIVE STRESS; PROTEIN MODIFICATIONS; DAMAGE; MALONDIALDEHYDE; NITROXIDE; RATS;

D O I：

10.1039/c7cc03387g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

引用

页码：10922 / 10925

页数：4

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