Intrinsic epileptogenicity in polymicrogyric cortex suggested by EEG-fMRI BOLD responses

被引:62
|
作者
Kobayashi, E [1 ]
Bagshaw, AP [1 ]
Jansen, A [1 ]
Andermann, F [1 ]
Andermann, E [1 ]
Gotman, J [1 ]
Dubeau, F [1 ]
机构
[1] McGill Univ, Montreal Neurol Hosp & Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada
关键词
D O I
10.1212/01.WNL.0000154640.23656.A3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Polymicrogyria (PMG) is a widespread cortical malformation frequently associated with seizures and EEG spikes. Its epileptogenicity is poorly understood. Nine patients with simultaneous EEG and fMRI were studied to assess the blood oxygenation level-dependent response to spikes. Sixteen of 18 studies showed responses, with maximum activation involving the lesion in 61.5%, but often limited to a small fraction of that lesion, suggesting intrinsic epileptogenicity in small areas of the PMG cortex.
引用
收藏
页码:1263 / 1266
页数:4
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