Molecular epidemiological features of Mycobacterium tuberculosis in an endemic region of Henan Province, China

被引:0
|
作者
Li, H. [1 ]
Yang, H. Y. [1 ]
Ma, X. G. [1 ]
Ma, S. W. [1 ]
Zhang, Y. [2 ]
机构
[1] Henan Ctr Dis Control & Prevent, Zhengzhou 450016, Peoples R China
[2] Johns Hopkins Univ, W Harry Feinstone Dept Mol Microbiol & Immunol, Bloomberg Sch Publ Hlth, Baltimore, MD USA
关键词
Mycobacterium tuberculosis; prevalence; drug resistance; Beijing family; MIRU-VNTR;
D O I
10.5588/ijtld.11.0423
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Henan Province is one of the regions with the highest tuberculosis (TB) burden in China. Among isolates collected from Zhongmou County, Henan, 21.28% (10/47) of those from 2001 and 22.95% (10/61) from 2007 were resistant to at least one drug (isoniazid, rifampicin, ethambutol or streptomycin); 90.74% (98/108) of the isolates were from the Beijing family, and 108 exhibited 105 different mycobacterial interspersed repetitive units-variable number of tandem repeats patterns. This study preliminarily reveals that Henan Province is still a high prevalence region for drug-resistant TB, and strains collected from local TB cases have diverse genotypes, of which the Beijing family type is predominant.
引用
收藏
页码:1097 / 1099
页数:3
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