Mixed shell mesoporous silica nanoparticles for controlled drug encapsulation and delivery

Aim: Smart mesoporous silica nanoparticles (MSNs) with mixed polymeric shell (MS-MSNs) were prepared to realize controlled encapsulation and responsive delivery of anticancer drugs. Materials & methods: Two kinds of polymers, including nonthermoresponsive poly(ethylene glycol) and thermoresponsive poly(Nisopropyl acrylamide), were grafted onto the outlets of the MSNs through acidic liable Schiff base bonds. Results: Poly(N-isopropyl acrylamide) chains could control the release rate of drugs through phase transition, while poly(ethylene glycol) chains could maintain the colloid stability of MSNs. Drugs can be released through the gradual hydrolysis of Schiff base bonds in tumor acidic environment. Conclusion: The MS-MSNs gave consideration to both the responsiveness and stability of carriers, and could realize the release of drugs as much as possible in tumor tissues.