Prevalence, risk factors and survival of lung cancer in the idiopathic pulmonary fibrosis

被引：32

作者：

Lee, Kyung Jong ^{[2
]}

Chung, Man Pyo ^{[2
]}

Kim, Young Whan ^{[3
]}

Lee, Jae Ho ^{[3
]}

Kim, Kyu-Sik ^{[4
]}

Ryu, Jeong Seon ^{[5
]}

Lee, Hong Lyeol ^{[5
]}

Park, Sung Woo ^{[6
]}

Park, Choon Sik ^{[6
]}

Uh, Soo-Tak ^{[6
]}

Lee, Yong Chul ^{[7
]}

Park, Seoung Ju ^{[7
]}

Kim, Kwan Hyoung ^{[8
]}

Jeon, Young June ^{[9
]}

Choi, Won Il ^{[9
]}

Park, Yong Bum ^{[10
]}

Kim, Dong Soon ^{[11
]}

Jeong, Sung Hwan ^{[12
]}

Lee, Jin Hwa ^{[13
]}

Park, Moo Suk ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Pulm & Crit Care Med, Seoul, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea

[4] Chonnam Natl Univ, Coll Med, Dept Internal Med, Kwangju, South Korea

[5] Inha Univ, Coll Med, Dept Internal Med, Inchon, South Korea

[6] Soon Chun Hyang Univ, Coll Med, Dept Internal Med, Asan, South Korea

[7] Chonbuk Natl Univ, Coll Med, Dept Internal Med, Jeonju, South Korea

[8] Catholic Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[9] Keimyung Univ, Sch Med, Dept Internal Med, Taegu, South Korea

[10] Hallym Univ, Coll Med, Dept Internal Med, Chunchon, South Korea

[11] Univ Ulsan, Asan Med Ctr, Div Pulm & Crit Care Med, Dept Internal Med, Ulsan, South Korea

[12] Gachon Univ, Coll Med, Dept Internal Med, Inchon, South Korea

[13] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea

来源：

THORACIC CANCER | 2012年 / 3卷 / 02期

关键词：

idiopathic pulmonary fibrosis; lung cancer; prevalence; INTERSTITIAL PNEUMONIA; ALVEOLITIS; CARCINOMA; DEATH;

D O I：

10.1111/j.1759-7714.2011.00107.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The aim of this study was to evaluate the prevalence, risk factors, and survival of lung cancer in patients with idiopathic pulmonary fibrosis (IPF). Methods: IPF with lung cancer from tertiary hospitals consisted of 1685 patients who had been diagnosed between 2003 and 2007. We reviewed their medical records retrospectively to evaluate the prevalence, risk factors and prognosis of lung cancer in IPF patients. Results: Among all patients with IPF, 114 cases (6.8%) had lung cancer with IPF. The incidence of lung cancer in patients with IPF was 1.03 persons per 100 person-year (25 patients/2408 years). Most cases of lung cancer (73/114, 68.9%) were located in IPF-associated areas; the lung cancer typically developed in peripheral and lower lobe areas. The study revealed that forced vital capacity (% predicted) at the initial diagnosis and development of lung cancer were independent prognostic factors in patients with IPF. Conclusions: Lung cancer in patients with IPF was significantly related with the IPF prognosis. An active evaluation should be performed in patients with IPF to detect lung cancer early.

引用

页码：150 / 155

页数：6

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