Multidomain Frailty as a Therapeutic Target in Elderly Patients with Heart Failure

被引:12
|
作者
Sunayama, Tsutomu [1 ]
Matsue, Yuya [1 ]
Dotare, Taishi [1 ]
Maeda, Daichi [1 ]
Iso, Takashi [1 ]
Morisawa, Tomoyuki [2 ]
Saitoh, Masakazu [2 ]
Yokoyama, Miho [1 ]
Jujo, Kentaro [3 ]
Takahashi, Tetsuya [2 ]
Minamino, Tohru [1 ,4 ]
机构
[1] Juntendo Univ, Dept Cardiovasc Biol & Med, Grad Sch Med, Tokyo, Japan
[2] Juntendo Univ, Dept Phys Therapy, Fac Hlth Sci, Tokyo, Japan
[3] Nishiarai Heart Ctr Hosp, Dept Cardiol, Tokyo, Japan
[4] Japan Agcy Med Res & Dev, Japan Agcy Med Res & Dev Core Res Evolut Med & Te, Tokyo, Japan
关键词
Cognitive dysfunction; Cognitive frailty; Physical frailty; Resistance exercise; Respiratory muscle training; Social disconnection; Social frailty; OLDER-ADULTS; MUSCLE DYSFUNCTION; PHYSICAL FRAILTY; SOCIAL FRAILTY; CARDIAC REHABILITATION; CARDIOVASCULAR-DISEASE; COGNITIVE STATUS; MORTALITY; INTERVENTION; ASSOCIATION;
D O I
10.1536/ihj.21-839
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Heart failure and frailty share aging as a strong risk factor. The prevalence of frailty has been shown to be particularly high in elderly patients with heart failure. Moreover, it is important not to confine frailty to physical aspects. Rather, it should be considered to consist of multiple domains, including physical disability, psychiatric disorders, cognitive impairment, depression, and social disconnection. Development of interventions that can improve frailty domains are not well established, although observational studies have evaluated the association of various frailty domains and their prognostic impact. Some interventions, including resistance exercise, functional exercise, and respiratory muscle training have been demonstrated to hold potential for improving physical frailty. In terms of cognitive dysfunction. previous studies have demonstrated that exercise therapy is also effective for cognitive dysfunction. The social domain of frailty is one of the least investigated domains, particularly in patients with heart failure. However, heart failure is also strongly associated with physical frailty and cognitive impairment and has a poor prognosis in old patients. The prevalence of social frailty in elderly patients who need hospitalization due to heart failure is higher than previously thought. Very few studies have tested interventions targeting social frailty. Frailty and heart failure affect each other, and both are becoming increasingly important in society. In this article, we review the physical, cognitive, and social domains of frailty and the possible interventions to improve them in patients with heart failure.
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页码:1 / 7
页数:7
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