Cutaneous manifestations in antiphospholipid syndrome

被引:6
|
作者
Caporuscio, S. [1 ]
Sorgi, M. L. [2 ]
Nistico, S. [3 ]
Pranteda, G. [4 ]
Bottoni, U. [3 ]
Carboni, I. [5 ]
Del Duca, E. [3 ]
Pranteda, G. [4 ]
机构
[1] Univ Roma La Sapienza, Polyclin Umberto I Hosp, Dept Med, Div Dermatol, I-00185 Rome, Italy
[2] Univ Roma La Sapienza, St Andrea Hosp, Dept Med, Div Rheumatol, I-00185 Rome, Italy
[3] Univ Catanzaro Magna Graecia, Dept Hlth Sci, Catanzaro, Italy
[4] Univ Roma La Sapienza, St Andrea Hosp, Dept Med, Div Dermatol, I-00185 Rome, Italy
[5] Univ Roma Tor Vergata, Dept Hlth Syst, Div Dermatol, Rome, Italy
关键词
antiphosholipid syndrome; intravascular thrombosis; necrosis; ANTIBODY SYNDROME; NECROSIS; DIAGNOSIS;
D O I
10.1177/0394632015582344
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antiphospholipid syndrome (APS) is a hypercoagulable state that leads to thrombosis and recurrent pregnancy loss related to the presence of antiphospholipid antibodies (LAC, anticardiolipin, antiA2-glycoprotein). Among cutaneous manifestations, livedo reticularis is the most frequent form of APS. In the literature, there are rare cases associated with diffuse skin necrosis (widespread skin necrosis) and intravascular thrombosis in the small vessels of the dermis. We describe the case of a 44-year-old man with positive anticardiolipin antibodies and protein S deficiency that developed scattered, bullous skin lesions, haemorrhagic in appearance with signs of necrosis as first clinical manifestation of antiphospholipid syndrome.
引用
收藏
页码:270 / 273
页数:4
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