Photoinduced remote regioselective radical alkynylation of unactivated C-H bonds

被引：4
|
作者：
Hu, Qu-Ping [1 ]
Liu, Yu-Tao [1 ]
Liu, Yong-Ze [1 ]
Pan, Fei [1 ]
机构：
[1] Sichuan Normal Univ, Coll Chem & Mat Sci, 5 Jingan Rd, Chengdu 610068, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 14期
基金：
中国国家自然科学基金;
关键词：
C(SP(3))-H BOND; ACYL OXIMES; FUNCTIONALIZATION; GENERATION; ALKYLATION; CLEAVAGE; CYANATION; STRATEGY;
D O I：
10.1039/d1cc06885g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A method for the remote regioselective alkynylation of unactivated C(sp(3))-H bonds in diverse aliphatic amides by photogenerated amidyl radicals has been developed. The site-selectivity is dominated via a 1,5-hydrogen atom transfer (HAT) process of the amide. Mild reaction conditions and high regioselectivity are demonstrated in this methodology.
引用
收藏
页码：2295 / 2298
页数：4
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