Classification of Dengue Illness Based on Readily Available Laboratory Data

被引：25

作者：

Potts, James A. ^{[1
,2
]}

Thomas, Stephen J. ^{[3
]}

Srikiatkhachorn, Anon ^{[1
,2
]}

Supradish, Pra-on ^{[4
]}

Li, Wenjun ^{[1
,2
]}

Nisalak, Ananda ^{[3
]}

Nimmannitya, Suchitra ^{[4
]}

Endy, Timothy P. ^{[5
]}

Libraty, Daniel H. ^{[1
,2
]}

Gibbons, Robert V. ^{[3
]}

Green, Sharone ^{[1
,2
]}

Rothman, Alan L. ^{[1
,2
]}

Kalayanarooj, Siripen ^{[4
]}

机构：

[1] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA

[2] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA USA

[3] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand

[4] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand

[5] SUNY Upstate Med Univ, Dept Med, Syracuse, NY USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2010年 / 83卷 / 04期

基金：

美国国家卫生研究院;

关键词：

JAPANESE ENCEPHALITIS; HEMORRHAGIC-FEVER; CASE DEFINITIONS; SEVERITY; NEED; INFECTIONS; NICARAGUA; FEATURES; CHILDREN; SYSTEM;

D O I：

10.4269/ajtmh.2010.10-0135

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The aim of this study was to examine retrospective dengue-illness classification using only clinical laboratory data, without relying on X-ray, ultrasound, or percent hemoconcentration. We analyzed data from a study of children who presented with acute febrile illness to two hospitals in Thailand. Multivariable logistic regression models were used to distinguish: (1) dengue hemorrhagic fever (DHF) versus dengue fever (DF), (2) DHF versus DF + other febrile illness (OFI), (3) dengue versus OFI, and (4) severe dengue versus non-severe dengue + OFI. Data from the second hospital served as a validation set. There were 1,227 patients in the analysis. The sensitivity of the models ranged from 89.2% (dengue versus OF!) to 79.6% (DHF versus DF). The models showed high sensitivity in the validation dataset. These models could be used to calculate a probability and classify patients based on readily available clinical laboratory data, and they will need to be validated in other dengue-endemic regions.

引用

页码：781 / 788

页数：8

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