Sirolimus for the treatment of juvenile nasopharyngeal angiofibroma

被引：8

作者：

Fernandez, Karen S. ^{[1
]}

de Alarcon, Alessandro ^{[2
]}

Adams, Denise M. ^{[3
]}

Hammill, Adrienne M. ^{[4
]}

机构：

[1] Stanford Univ, Valley Childrens Hosp, Canc & Blood Disorders Ctr, Solid Tumor Program, 9300 Valley Childrens Pl, Madera, CA 93720 USA

[2] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Div Pediat Otolaryngol Head & Neck Surg, Ctr Pediat Voice Disorders, Cincinnati, OH USA

[3] Harvard Med Sch, Boston Childrens Hosp, Div Hematol Oncol, VAC, Boston, MA 02115 USA

[4] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Canc & Blood Dis Inst, Hemangioma & Vasc Malformat Ctr, Cincinnati, OH USA

来源：

PEDIATRIC BLOOD & CANCER | 2020年 / 67卷 / 04期

关键词：

adolescents; angiofibromas; antiangiogenic drug; mTOR inhibitor; rare tumors; sirolimus; VASCULAR ANOMALIES; MTOR;

D O I：

10.1002/pbc.28162

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Juvenile nasopharyngeal angiofibroma (JNA) is a pathologically benign yet locally aggressive and destructive tumor that develops in the choana and nasopharynx. Historical treatment of JNA has included embolization, surgical resection, and radiation. Here, we describe three patients who received therapy with the mTOR inhibitor sirolimus with improvement in clinical symptoms, imaging, and overall well-being.

引用

页数：4

共 50 条

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