Serotonin receptor 5-HT5A in rat hippocampus decrease by leptin treatment

被引：17

作者：

Garcia-Alcocer, Guadalupe ^{[1
]}

Rodriguez, Angelina ^{[1
]}

Moreno-Layseca, Paulina ^{[1
]}

Berumen, Laura C. ^{[1
]}

Escobar, Jesica ^{[1
]}

Miledi, Ricardo ^{[2
,3
]}

机构：

[1] Univ Autonoma Queretaro, Fac Quim, Ctr Univ, Cerro De Las Campanas 76010, Queretaro, Mexico

[2] Univ Nacl Autonoma Mexico, Inst Neurobiol, Juriquilla 76230, Queretaro, Mexico

[3] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

来源：

NEUROSCIENCE LETTERS | 2010年 / 486卷 / 03期

关键词：

Serotonin receptor; 5 HT5A receptor; Leptin; Hippocampus; Serotonin; MESSENGER-RNA EXPRESSION; NEUROGENESIS; LOCALIZATION; HYPOPHAGIA; 5-HT(5A);

D O I：

10.1016/j.neulet.2010.09.045

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

5-Hydroxytryptamine (5-HT) is involved in a variety of different physiological processes and behaviors through the activation of equally diverse receptors subtypes In this work we studied the changes on the expression of 5-HT5A receptors in rat hippocampus induced by leptin an adipocyte-derived hormone that has been reported to participate in the modulation of food Intake and in adult hippocampal neurogenesis To study the effect of leptin on the 5-HT5A receptor gene expression a qRT-PCR was used and the distribution of those receptors in the hippocampus was visualized by immunohistochemistry Rats were separated in four groups control (untreated rats) leptin-treated serotonin-treated and leptin + serotonin treated The results showed that even though the 5-HT5A gene expression did not change in the hippocampus of any of the treated groups in the rats treated with leptin and serotonin the specific immunostaining for the 5-HT5A serotonin receptor decreased significantly in the dentate gyms (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：171 / 173

页数：3

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