An Efficient and Ecofriendly Three-Component Reaction for the Rapid Synthesis of 2-Amino-4H-chromenes Catalyzed by a DABCO-Based Ionic Liquid

被引：10
|
作者：
Li, Cheng-Bin
Li, Yu-Wei
Xu, Da-Zhen [1 ]
机构：
[1] Nankai Univ, Coll Chem, State Key Lab, Natl Engn Res Ctr Pesticide Tianjin, Tianjin 300071, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2018年 / 50卷 / 18期
基金：
中国国家自然科学基金;
关键词：
2-amino-4H-chromene; green chemistry; ionic liquid; multicomponent reaction; salicylaldehyde; ONE-POT SYNTHESIS; 3 COMPONENT REACTIONS; HIGHLY EFFICIENT; MULTICOMPONENT SYNTHESIS; 3-SUBSTITUTED INDOLES; MICHAEL REACTION; MILD CONDITION; AQUEOUS-MEDIA; DERIVATIVES; GREEN;
D O I：
10.1055/s-0037-1610123
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient, economical, and green strategy for the construction of biologically relevant 2-amino-4H-chromene scaffolds via a tandem Knoevenagel-Pinner cyclization-Michael reaction has been successfully developed. In the presence of DABCO-based ionic liquids, two different 2-amino-4H-chromene derivatives, 2-amino-4-(indol-3yl)-4H-chromenes and 2-amino-4-(pyrazol-4-yl)-4H-chromenes, were prepared in good to excellent yields (81-97%) within short reaction times under mild conditions. All the products are purified by simple crystallization. The catalyst could be recycled for at least five times.
引用
收藏
页码：3708 / 3714
页数：7
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