The MCM helicase: linking checkpoints to the replication fork

被引：30
|
作者：
Forsburg, Susan L. [1 ]
机构：
[1] Univ So Calif, Mol & Computat Biol Sect, Los Angeles, CA 90089 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷
关键词：
Cds1; minichromosome maintentance (MCM); Mrc1; Rad51; Rad53; Rhp51; Schizosocchoromyces pombe; SINGLE-STRANDED-DNA; S-PHASE CHECKPOINT; PROTEINS; ACTIVATION; DAMAGE; MRC1; COMPLEX; KINASE; ATR; INSTABILITY;
D O I：
10.1042/BST0360114
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The MCM (minichromosome maintenance) complex is a helicase which is essential for DNA replication. Recent results suggest that the MCM helicase is important for replication fork integrity, and may function as a target of the replication checkpoint. Interactions between MCM proteins, checkpoint kinases, and repair and recovery proteins suggest that MCMs are proximal effectors of replication fork stability in the cell and are likely to play an important role in maintaining genome integrity.
引用
收藏
页码：114 / 119
页数：6
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