Transition metal-catalyzed intermolecular [5+2] and [5+2+1] cycloadditions of allenes and vinylcyclopropanes

被引：140

作者：

Wegner, HA

de Meijere, A

Wender, PA ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Mol Pharmacol, Stanford, CA 94305 USA

[3] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 18期

关键词：

D O I：

10.1021/ja043671w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Initial examples of the intermolecular Rh(I)-catalyzed [5+2] cycloaddition reaction of bifunctional allenes and vinylcyclopropanes are described. The reactions proceed with facility and in yields of up to 99% with a variety of alkyne-, ester-, styrene-, or cyano-substituents on the allene to afford the corresponding cycloadducts. In the presence of CO, the reaction proceeds to an eight-membered ring cycloadduct and its transannularly closed product, providing the first example of a three-component [5+2+1] cycloaddition with allenes. Copyright © 2005 American Chemical Society.

引用

页码：6530 / 6531

页数：2

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