Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure

被引：80
|
作者：
Wu, Hong-Jin [1 ]
Zhang, Cheng-Ying [2 ]
Zhang, Sai [1 ]
Chang, Min [1 ]
Wang, Hong-Yun [1 ]
机构：
[1] Peking Univ Third Hosp, Beijing Haidian Hosp, Haidian Sect, 29th Zhongguancun Setreet, Beijing 100080, Peoples R China
[2] Tradit Chinese Med Hosp Beijing Huairou Beijing, Beijing, Peoples R China
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2016年 / 39卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Myocardial infarction (MI); Heart failure (HF); Microarray; Noncoding RNAs; Circular RNAs; LONG NONCODING RNAS; HYPERTROPHIC CARDIOMYOPATHY; THERAPEUTIC TARGETS; INJURY; UPDATE;
D O I：
10.1159/000445617
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Background/Aims: Myocardial infarction (MI) is a serious complication of atherosclerosis associated with increasing mortality attributable to heart failure. This study is aimed to assess the global changes in and characteristics of the transcriptome of circular RNAs (circRNAs) in heart tissue during MI induced heart failure (HF). Methods: Using a post-myocardial infarction (MI) model of HF in mice, we applied microarray assay to examine the transcriptome of circRNAs deregulated in the heart during HF. We confirmed the changes in circRNAs by quantitative PCR. Results: We revealed and confirmed a number of circRNAs that were deregulated during HF, which suggests a potential role of circRNAs in HF. Conclusions: The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment. (C) 2016 The Author(s) Published by S. Karger AG, Basel
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收藏
页码：205 / 216
页数：12
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