Visible-light induced green synthesis of y-deuterated carbonyl compounds

被引：3
|
作者：
Hu, Lifu [1 ]
Li, Ruining [1 ]
Deng, Wei [2 ]
Sun, Zhankui [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Oncol, Shanghai 200125, Peoples R China
来源：
TETRAHEDRON LETTERS | 2022年 / 101卷
关键词：
Deuteration; Radical addition; Green synthesis; Visible-light; Introduction; DEUTERIUM; TRITIATION; TRITIUM; D2O;
D O I：
10.1016/j.tetlet.2022.153914
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Deuteration isa widely used labelling technique. Through a visible-light induced desulfurization and rad-ical addition process in EtOAc-D2O, we were able to develop the direct synthesis of y-deuterated carbonyl compounds from a-sulfide ketones and alkenes. Products with different functionalities were efficiently synthesized with high-deuteration. This mild and metal-free method provides a valuable tool for medic-inal and synthetic chemists. (C) 2022 Elsevier Ltd. All rights reserved.
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页数：4
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