Control of neuronal network organization by chemical surface functionalization of multi-walled carbon nanotube arrays

被引:19
|
作者
Liu, Jie [1 ]
Appaix, Florence [2 ,3 ]
Bibari, Olivier [1 ]
Marchand, Gilles [1 ]
Benabid, Alim-Louis [1 ]
Sauter-Starace, Fabien [1 ]
De Waard, Michel [2 ,3 ]
机构
[1] CEA, LETI Minatec, F-38054 Grenoble 9, France
[2] Grenoble Inst Neurosci, INSERM, U836, F-38042 Grenoble 09, France
[3] Univ Grenoble 1, Grenoble, France
关键词
IN-VITRO; BIOCOMPATIBILITY; GROWTH;
D O I
10.1088/0957-4484/22/19/195101
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Carbon nanotube substrates are promising candidates for biological applications and devices. Interfacing of these carbon nanotubes with neurons can be controlled by chemical modifications. In this study, we investigated how chemical surface functionalization of multi-walled carbon nanotube arrays (MWNT-A) influences neuronal adhesion and network organization. Functionalization of MWNT-A dramatically modifies the length of neurite fascicles, cluster inter-connection success rate, and the percentage of neurites that escape from the clusters. We propose that chemical functionalization represents a method of choice for developing applications in which neuronal patterning on MWNT-A substrates is required.
引用
收藏
页数:11
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