Pulmonary toxoplasmosis in 21 HIV-infected patients

Objectives: Assess expression of pulmonary toxoplasmosis, the second most frequent localization after brain, in patients infected with the human immunodeficiency virus (HIV). Methods: Twenty-one EW-infected patients (18M, 3F) were admitted for pulmonary toxoplasmosis between September 1987 and February 1995, Mode of HIV transmission was unprotected homosexual sexual activity (n=16), intravenous drug abuse (n=3) and transfusion (n=2). Results: Isolated pulmonary toxoplasmosis was found in 11 patients, In 10 patients pulmonary toxoplasmosis was associated with cerebral (n=4), bone marrow (n=2), ocular (n=1) and multifocal (n=3) localizations. Seven patients were admitted for acute pulmonary distress. Fever (reported for 20 patients) and nonproductive cough (reported for 16 patients) were the most common clinical symptoms. Chest roentgenogram revealed bilateral pulmonary infiltrates in 16 (76%) patients. Mean absolute CD4 count was 25+/-57 (range 0-110), Serologic evidence of past infection was observed in 18 patients, Serology tests were not done for two patients and negative for one, Two patients presented co-infection with Pneumocystis carinii. Fourteen patients had elevated serum lactic dehydrogenase (LDH) concentration. Among those, 4 patients whose LDH concentration was elevated more than ten fold died of respiratory distress. Patients received pyrimethamine and sulfadiazine (n=13) or clindamycin (n=8). Seven patients died during the first month after diagnosis was made, For the other patients, mean survival was 8 months. No relapse of toxoplasmosis was observed. All the patients took a secondary prophylaxis. Conclusion: No difference between patient with isolated pulmonary toxoplasmosis and patients with associated extrapulmonary localization was noted for clinical, biological, radiological presentations and outcome.