Detection of physiological potassium ions level in human serum by Raman scattering spectroscopy

被引:14
|
作者
Su, Hongyang [1 ]
Ruan, Weidong [1 ]
Ye, Shunsheng [1 ]
Liu, Yawen [1 ]
Sui, Huimin [1 ]
Li, Zihui [1 ]
Sun, Xiaoying [2 ]
He, Chengyan [2 ]
Zhao, Bing [1 ]
机构
[1] Jilin Univ, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China
[2] Jilin Univ, China Japan Union Hosp, Changchun 130033, Peoples R China
基金
中国国家自然科学基金;
关键词
Potassium; Serum; Raman; Hydrophobic; Potassium-sodium cobaltinitrite; G-QUADRUPLEX CONFORMATION; ELECTROCHEMICAL SENSOR; IMPEDANCE SPECTROSCOPY; LOW-COST; SURFACE; APTASENSOR; SODIUM; COBALTINITRITE; NANOPARTICLES; BIOSENSOR;
D O I
10.1016/j.talanta.2016.09.010
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Potassium ions play pivotal roles in biological systems. A simple and effective Raman scattering-based protocol for the detection of physiological potassium ions level in human serum has been developed. We employed sodium cobaltinitrite, which can react with potassium to form potassium-sodium cobaltinitrite. Combining hydrophobic surface and the Raman scattering for potassium detection, highly reproducible Raman spectra of the potassium-sodium cobaltinitrite can be obtained with highly sensitivity. The characteristic Raman peak of potassium-sodium cobaltinitrite was used to distinguish it from other kinds of matter, and its intensity was used to monitor the amounts of potassium ions in human serum. Because of the contribution of the hydrophobic surface aggregation to the Raman, this protocol has great potential for practical detection of the potassium in human serum and has extended the measuring potential use in the detection of potassium in human serum by spectrum method.
引用
收藏
页码:743 / 747
页数:5
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