A lectin from Musca domestica pupae stimulates B cell proliferation and enhances IL-12 production via ERK1/2-NF-κB signaling pathways

被引：4

作者：

Cao, Xiaohong ^{[1
]}

Li, Yuanyuan ^{[1
]}

Hou, Lihua ^{[1
]}

Zhou, Minghui ^{[1
]}

Wang, Zhuo ^{[1
]}

Cui, Qi ^{[1
]}

Gao, Xiaohe ^{[1
]}

Wang, Chunling ^{[1
]}

机构：

[1] Tianjin Univ Sci & Technol, Minist Educ, Key Lab Food Nutr & Safety, Tianjin, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2011年 / 33卷 / 08期

关键词：

B cell; Interleukin-12; Lectin; Musca domestica pupa; NF-KAPPA-B; ERK; ACTIVATION; SECRETION; KINASES; ALPHA; BETA;

D O I：

10.1007/s10529-011-0601-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A D-galactose-specific lectin, MW = 40 kDa, had been purified from pupae of Musca domestica (MPL). MPL significantly promoted the proliferation of B cells and enhanced the production of IL-12 in a dose-dependent manner. MPL stimulated I kappa B-alpha degradation, NF-kappa B translocation and ERK1/2 phosphorylation which played an upstream role for NF-kappa B in MPL-induced B cells. Moreover, MPL regulated cell proliferation and induced IL-12 production through ERK1/2-NF-kappa B signaling pathway.

引用

页码：1545 / 1550

页数：6

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