Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR

被引：6

作者：

Cannon, J. ^{[1
,2
]}

Fitzgerald, B. ^{[1
,2
]}

Seed, M. ^{[3
]}

Agius, R. ^{[3
]}

Jiwany, A. ^{[4
]}

Cullinan, P. ^{[1
,2
]}

机构：

[1] Royal Brompton & Harefield NHS Trust, Dept Occupat & Environm Med, London SW3 6LR, England

[2] Univ London Imperial Coll Sci Technol & Med, London, England

[3] Univ Manchester, Ctr Occupat & Environm Hlth, Manchester, Lancs, England

[4] GlaxoSmithKline, Dept Occupat Hlth, Brentford, Middx, England

来源：

OCCUPATIONAL MEDICINE-OXFORD | 2015年 / 65卷 / 03期

关键词：

Asthma hazard index; respiratory sensitizer; tafenoquine; HAZARD; RELAPSE;

D O I：

10.1093/occmed/kqu193

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We report occupational asthma and rhinitis in a formulation pharmacist, employed in the development of tafenoquine. Tafenoquine is a new anti-malarial drug in development; the pure drug substance has an asthma hazard index of zero and previously was not known to be a respiratory sensitizing agent. The implications of this finding for the refinement of quantitative structural analysis of asthmagenic chemicals are discussed.

引用

页码：256 / 258

页数：3

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