The role of cannabinoid system on immune modulation:: Therapeutic implications on CNS inflammation

被引:28
|
作者
Correa, F
Mestre, L
Molina-Holgado, E
Arévalo-Martín, A
Docagne, F
Romero, E
Molina-Holgado, F
Borrell, J
Guaza, C
机构
[1] CSIC, Inst Cajal, Neuroimmunol Grp, Neural Plast Unit, E-28002 Madrid, Spain
[2] Hosp Nacl Paraplejicos, Neuroinflammat Grp, Toledo, Spain
[3] Univ Cambridge, Dept Vet Clin Med, Neurol Unit, Cambridge, England
关键词
cannabinoids; immune function; neuroinflammation; glial cells; multiple sclerosis;
D O I
10.2174/1389557054368790
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
There is a growing amount of evidence suggesting that cannabinoids may be neuroprotective in CNS inflammatory conditions. Advances in the understanding of the physiology and pharmacology of the cannabinoid system have increased the interest of cannabinoids as potential therapeutic targets. Cannabinoid receptors and their endogenous ligands, the endocannabinoids, have been detected in cells of the immune system, as well as in brain glial cells. In the present review it is summarized the effects of cannabinoids on immune reactivity and on the regulation of neuroinflammatory processes associated with brain disorders with special attention to chronic inflammatory demyelinating diseases such as multiple sclerosis.
引用
收藏
页码:671 / 675
页数:5
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