Mechanisms regulating epithelial stratification

被引:238
|
作者
Koster, Maranke I. [1 ]
Roop, Dennis R. [1 ]
机构
[1] Univ Colorado Denver, Ctr Hearing Sci, Dept Dermatol, Charles C Gate Program Regenerap Med & Stem Cell, Aurora, CO 80010 USA
关键词
epidermal morphogenesis; barrier formation; p63;
D O I
10.1146/annurev.cellbio.23.090506.123357
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The epidermis is a stratified epithelium that functions as a barrier protecting the organism from dehydration, mechanical trauma, and microbial insults. This barrier function is established during embryogenesis through a complex and tightly controlled stratification program. Whereas the morphological changes that occur during epidermal development have been extensively studied, the molecular mechanisms that govern this process remain poorly understood. In this review we summarize the current advances that have been made in understanding the molecular mechanisms that regulate epidermal morphogenesis.
引用
收藏
页码:93 / 113
页数:21
相关论文
共 50 条
  • [1] Cellular mechanisms regulating epithelial morphogenesis and cancer invasion
    Gray, Ryan S.
    Cheung, Kevin J.
    Ewald, Andrew J.
    CURRENT OPINION IN CELL BIOLOGY, 2010, 22 (05) : 640 - 650
  • [2] Analysis of mechanisms in epithelial stratification induced by mesenchymal cells in the mouse vagina
    Asada, Taichi
    Ogawa, Minako
    Umezu, Tomohiro
    Tomooka, Yasuhiro
    ZOOLOGICAL SCIENCE, 2006, 23 (12) : 1219 - 1219
  • [3] Mechanisms Regulating Mitochondrial Transfer in Human Corneal Epithelial Cells
    Pal-Ghosh, Sonali
    Karpinski, Beverly A.
    Datta-Majumdar, Himani
    Datta, Soneha
    Dimri, Shelly
    Hally, Jordan
    Wehmeyer, Hugo
    Stepp, Mary Ann
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2024, 65 (13)
  • [4] Taking a Step Back: Insights into the Mechanisms Regulating Gut Epithelial Dedifferentiation
    Ouladan, Shaida
    Gregorieff, Alex
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (13)
  • [5] Molecular mechanisms regulating intestinal epithelial cell turnover by nutrients.
    Ruemmele, F
    Ruemmele, C
    Levy, E
    Seidman, E
    GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE, 1999, 23 (01): : 47 - 55
  • [6] Cellular and Molecular Mechanisms Regulating the Normal Physiological Function of the Epithelial Sodium Channel
    El-Aziz, Tuck M. Abd
    Soares, Antonio
    Mironova, Elena
    Stockand, James
    FASEB JOURNAL, 2022, 36
  • [7] Molecular mechanisms of microRNAs in regulating epithelial-mesenchymal transitions in human cancers
    Tang, Jinlong
    Li, Yuan
    Wang, Jingyu
    Wen, Zhineng
    Lai, Maode
    Zhang, Honghe
    CANCER LETTERS, 2016, 371 (02) : 301 - 313
  • [8] Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma
    Barbolina, Maria V.
    CANCERS, 2018, 10 (11)
  • [9] Molecular mechanisms regulating nitric oxide biosynthesis - Role of xenobiotics in epithelial inflammation
    Heck, DE
    BIOLOGICAL REACTIVE INTERMEDIATES V: BASIC MECHANISTIC RESEARCH IN TOXICOLOGY AND HUMAN RISK ASSESSMENT, 1996, 387 : 171 - 176
  • [10] DISTANCE MECHANISMS OF STRATIFICATION
    VANDENBERGHE, HL
    SOCIOLOGY AND SOCIAL RESEARCH, 1960, 44 (03): : 155 - 164