Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice

被引：21

作者：

Wang, Chengfen ^{[1
]}

Xia, Yujing ^{[1
]}

Zheng, Yuanyuan ^{[1
]}

Dai, Weiqi ^{[1
]}

Wang, Fan ^{[1
]}

Chen, Kan ^{[1
]}

Li, Jingjing ^{[1
]}

Li, Sainan ^{[1
]}

Zhu, Rong ^{[1
]}

Yang, Jing ^{[1
]}

Yin, Qin ^{[1
]}

Zhang, Huawei ^{[1
]}

Wang, Junshan ^{[1
]}

Lu, Jie ^{[1
]}

Zhou, Yingqun ^{[1
]}

Guo, Chuanyong ^{[1
]}

机构：

[1] Tongji Univ Med, Shanghai Peoples Hosp 10, Dept Gastroenterol, Shanghai 200072, Peoples R China

来源：

MEDIATORS OF INFLAMMATION | 2015年 / 2015卷

基金：

中国国家自然科学基金;

关键词：

EXPERIMENTAL LIVER-INJURY; KAPPA-B ACTIVATION; T-CELLS; AUTOPHAGY; INFLAMMATION; INHIBITION; PATHWAYS; STRESS;

D O I：

10.1155/2015/189785

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This study was designed to study the protective effects and mechanisms of N-acetylcysteine (NAC) in concanavalin A-induced hepatitis in mice. In this study, pretreatment with NAC ameliorated the histopathological changes and suppressed inflammatory cytokines in ConA-induced hepatitis. The expression of IL-2, IL-6, TNF-alpha and IFN-gamma was significantly reduced in the NAC-treated groups. NAC activated PI3K/Akt pathway and inhibited the activation of NF-kappa B. Additionally, NAC reduced autophagosome formation, as assessed by detecting the expression of LC3 and Beclin 1. Our results demonstrate that NAC can alleviate ConA-induced hepatitis by regulating the PI3K/Akt pathway and reducing the late stages of autophagy. Our results described a new pharmaceutical to provide more effective therapies for immune hepatitis.

引用

页数：17

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