Acute Tubular Necrosis Associated with Angiotensin Receptor-neprilysin Inhibitor

被引：2
|
作者：
Kim, Moo Jun [1 ]
Jang, Ha Nee [2 ]
Song, Haa-Na [3 ]
Lee, Jong Sil [4 ]
Kang, Min Gyu [5 ]
机构：
[1] Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Internal Med, Coll Med, Jinju, South Korea
[2] Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Internal Med, Div Nephrol,Coll Med, Jinju, South Korea
[3] Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Div Hematol & Oncol, Dept Internal Med,Coll Med, Jinju, South Korea
[4] Gyeongsang Natl Univ, Inst Hlth Sci, Gyeongsang Natl Univ Hosp, Dept Pathol,Coll Med, Jinju, South Korea
[5] Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Div Cardiol, Dept Internal Med,Coll Med, Jinju, South Korea
来源：
INTERNAL MEDICINE | 2022年 / 61卷 / 10期
关键词：
angiotensin receptor-neprilysin inhibitor; heart failure with reduced ejection fraction; acute tubular necrosis; HFrEF; HEART-FAILURE;
D O I：
10.2169/internalmedicine.8373-21
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), significantly reduces mortality and morbidity in patients with chronic heart failure with a reduced ejection fraction (HFrEF). However, a considerable number of patients treated with sacubitril/valsartan experience hypotension, oliguria, progressive azotemia, and renal failure as adverse events. These issues have been linked to significant gaps in the usage and dosing of guideline-directed medical therapy with ARNI in patients with HFrEF. We herein report a relevant case of pathologically proven acute tubular necrosis after the first dose of sacubitril/valsartan, highlighting the importance of optimizing the medical therapy in an outpatient with HFrEF.
引用
收藏
页码：1573 / 1576
页数：4
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