Potential role of synthetic curcumin analogs as antibacterial, antioxidant and anticancer agent

Curcumin is naturally found in the dried rhizome of Curcuma longa plant and chemically it is polyphenol compound and has enormous biological applications such as antioxidant, anticancer, antibacterial, anti-Alzheimer's disease etc. In this study we investigated in-vitro antioxidant, anticancer and antibacterial potentials of the synthesized curcumin analogs (H1-H2) and have showed promising antioxidant activity by scavenging DPPH and ABTS free radicals at 1000 to 62.5 mu g/mL concentration. Compound (H1) showed anti-proliferative activity with IC50 254.16, 262.4 and 252.11 mu g/mL in 1000 to 62.6 mu g/mL concentration, while curcumin (H2) showed comparable anti-proliferative activity with IC50 of 477.8, 254.8 and 462.6 mu g/mL against 3 T3, HeLa and MCF-7 cell lines respectively. Antibacterial activity showed that Proteus mirabilis, Escherichia coli, Staphylococcus aureus and Bacillus cereus were significantly susceptible towards both synthesized curcumin analogs (H1-H2). It was concluded from this study that the synthesized compounds could be helpful in the treatment of cancer and bacterial infection by further exploring their pharmacological profile.