α-Synuclein as a Diagnostic Marker and Therapeutic Target for Parkinson Disease

被引：0
|
作者：
Luan Ming-Yue [1 ]
Wang Zhao-Xia [1 ,2 ]
Deng Jian-Wen [1 ,2 ]
机构：
[1] Peking Univ First Hosp, Dept Neurol, Beijing 100034, Peoples R China
[2] Beijing Key Lab Neurovasc Dis Discovery, Beijing 100034, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2022年 / 49卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Parkinson disease; alpha-synuclein; biomarkers; therapy; DETECT LEWY PATHOLOGY; RED-BLOOD-CELLS; CEREBROSPINAL-FLUID; POTENTIAL BIOMARKER; PRESYNAPTIC PROTEIN; ALZHEIMERS-DISEASE; MUCOSA; PLASMA; SKIN; CSF;
D O I：
10.16476/j.pibb.2021.0346
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Parkinson disease (PD) is an insidious and progressive neurodegenerative disease. It is the second most common neurodegenerative disease affecting 1%-3% of the population over the age of 65. While the etiology of PD is complex, alpha-synuclein (alpha-syn) misfolding and aggregation is identified as the hallmark of PD. Due to lack of the reliable biomarkers, early diagnosis of this disease is difficult. In this review, we discuss recent research progresses in the development of PD biomarkers based on the detection of alpha-synuclein from different samples, including body fluids (cerebrospinal fluid, blood, saliva) and peripheral tissues (skin, olfactory mucosa, salivary gland, gut mucosa). Furthermore, we summarize the recent advances on the therapeutic approaches targeting alpha-synuclein in treating PD.
引用
收藏
页码：86 / 99
页数：14
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